Stefan Diez

Structural mechanism of nuclear membrane sealing by LEM2-ESCRT-III

The paper elucidates the structural mechanism of nuclear membrane sealing by LEM2-ESCRT-III through a combination of biochemical and structural methods.

Practically Error-Free Junctions Enable Solving Large Instances of Exact Cover Problems Using Network-Based Biocomputation

This paper improves network-based biocomputation by reducing junction errors, enabling solving large Exact Cover problems with up to 33 million solution spaces.

Programmable microactuators phase-lock cilia to local oscillatory flow

The paper introduces programmable microactuators to study ciliary responses to local flows, finding phase-locking and frequency shifts in Chlamydomonas reinhardtii cilia.

Programmable DNA Origami Caps for Site-Selective Functionalization of Microtubule Tips and Lattice Defects

This paper develops DNA origami caps to selectively functionalize microtubule tips and lattice defects, enabling controlled cargo capture and dynamic visualization.

Dynamic switching of cell-substrate contact sites allows gliding diatoms to modulate the curvature of their paths

This study shows how diatoms switch between one- and two-raphe contact gliding to modulate path curvature by dynamically altering cell-substrate contact sites.

Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization

This study shows that KIF11 mutations impair microtubule dynamics and dendritic arborization in neurons, contributing to intellectual disabilities.

Kinesin-induced buckling reveals the limits of microtubule self-repair

This study shows that kinesin-driven microtubule buckling causes severe lattice damage that often exceeds microtubule self-repair capacity, leading to breakage, but survival is enhanced with intracellular factors.

Microtubule lattice defects facilitate spastin-mediated severing

This study shows that microtubule lattice defects accelerate spastin-mediated severing by reducing the number of tubulin subunits needed for cleavage, without preferential spastin binding to defects.

MAP65-1/PRC1 reinforces microtubules through nucleation

The paper shows MAP65-1/PRC1 promotes microtubule nucleation on damaged lattices under mechanical stress, stabilizing microtubules and reinforcing their alignment with stress.

Tau accelerates tubulin exchange in the microtubule lattice

This study shows tau accelerates tubulin exchange in microtubule lattices by stabilizing longitudinal and destabilizing lateral interactions, challenging its traditional role as a stabilizer.

Altered lysosomal biology impairs motor neuron survival via TFEB dysregulation in spinal muscular atrophy

The paper shows that TFEB activation restores lysosomal function and improves motor neuron survival in SMA, highlighting its potential as a therapeutic target.

Twist - torsion coupling in beating axonemes

The paper measures torsion and twist in axonemes of Chlamydomonas reinhardtii, finding co-rotation between cross-section and bending plane, indicating twist-torsion coupling.

Tubulin tyrosination/detyrosination governs the spatial segregation of intraflagellar transport trains on axonemal microtubule doublets

This study shows that tubulin tyrosination/detyrosination governs the spatial segregation of IFT trains on ciliary microtubules, preventing traffic jams.

A floor-field model of tau-taxol competition explains tau envelope dynamics on taxol-stabilized microtubules

This study uses a floor-field model to show that tau-taxol competition on microtubules explains tau envelope formation and stability without requiring tau-tau interactions.

Gliding motility of the diatom Craspedostauros australis correlates with the intracellular movement of raphid-specific myosins

This study identifies and characterizes raphid diatom-specific myosins in Craspedostauros australis, showing that only CaMyoB-D moves during gliding, suggesting a role in force generation.

Transport efficiency of membrane-anchored kinesin-1 motors depends on motor density and diffusivity

This study investigates how membrane-anchored kinesin-1 motors affect microtubule gliding velocity, finding that motor density and diffusivity significantly influence transport efficiency.