The mechanism of checkpoint-dependent DNA replication fork stabilization in human cells
Agostina P. Bertolin, Berta Canal, Mona Yekezare, Anne E. Early, Jingkun Zeng, Rachael Instrell, Michael Howell, John F.X. Diffley
This study identifies how the DNA damage checkpoint stabilizes replication forks by preventing excess origin firing and fork collapse through the regulation of PCNA and HLTF.
Molecular Cell · Jun 26, 2025Peer-reviewedCell Biology