Author
The Francis Crick InstituteORCID 0000-0001-8893-1827Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Thomas Pühringer, Berta Canal, Giacomo Palm…·Alessandro Costa
The paper reconstitutes the pre-Initiation Complex in yeast to determine how CMGE helicases form and function during DNA replication initiation.
Giacomo Palm, Agata Butryn, Berta Canal…·Alessandro Costa
The paper elucidates how Mcm10 facilitates the separation of converging replicative helicases during DNA replication initiation by stabilizing a structural intermediate.
Berta Canal, Agostina P. Bertolin, Guan Hwee Bernard Lee…·John F.X. Diffley
This study reveals DNA replication fork stabilization and restart mechanisms using biochemical reconstitution in budding yeast.
Agostina P. Bertolin, Berta Canal, Mona Yekezare…·John F.X. Diffley
This study identifies how the DNA damage checkpoint stabilizes replication forks by preventing excess origin firing and fork collapse through the regulation of PCNA and HLTF.