Author

Rachael Instrell

The Francis Crick InstituteORCID 0000-0002-4437-2952Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Agostina P. Bertolin· 1 shared Anne E. EarlyiD· 1 shared Berta CanaliD· 1 shared Jingkun ZengiD· 1 shared John F.X. DiffleyiD· 1 shared Michael HowelliD· 1 shared Mona Yekezare· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Agostina P. Bertolin

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1 paper

Recent·Most cited

Cell BiologyMolecular CellPeer-reviewedJun 26, 2025

The mechanism of checkpoint-dependent DNA replication fork stabilization in human cells

Agostina P. Bertolin, Berta Canal, Mona Yekezare…·John F.X. Diffley

This study identifies how the DNA damage checkpoint stabilizes replication forks by preventing excess origin firing and fork collapse through the regulation of PCNA and HLTF.

27 citationstop 2%

humanDNA methylation

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