Rhomboid protease RHBDL2 is a calcium-activated suppressor of EGFR signalling in keratinocytes.
Nicholas Johnson, Jan Dohnálek, Jana Březinová, Josef Čáslavský, Aneta Škarková, Njainday Pulo Jobe, Monika Fliegl, Květa Trávníčková, Emma Burbridge, Vahap Canbay, Chatpakorn Rassemeena Christiansen, Ulrich auf dem Keller, Juraj Lábaj, Olha Fedosieieva, Jan Prochazka, , Kvido Střı́šovský
This study identifies RHBDL2 as a calcium-activated rhomboid protease that suppresses EGFR signaling in keratinocytes by shedding its ectodomain, thereby limiting cell migration and invasion.
Cellular and Molecular Life Sciences · Aug 17, 2026Peer-reviewedCell Biology