Jan Brábek

This study identifies RHBDL2 as a calcium-activated rhomboid protease that suppresses EGFR signaling in keratinocytes by shedding its ectodomain, thereby limiting cell migration and invasion.

This study proposes integrating migrastatics into adaptive therapy to delay metastasis and improve cancer treatment outcomes.

The paper shows that altering eIF3 subunit levels affects the translatome, particularly impacting MAPK signaling and ribosomal protein expression in HeLa cells.