Colin Adrain

This study identifies RHBDL2 as a calcium-activated rhomboid protease that suppresses EGFR signaling in keratinocytes by shedding its ectodomain, thereby limiting cell migration and invasion.

This study shows that GIGYF2/4EHP-mediated translational repression helps maintain cellular homeostasis after ionizing radiation by preserving proteostasis and cell viability.

This study shows Fbxo42 promotes degradation of Ataxin-2 granules, enabling Xbp1 translation and triggering cell death during terminal UPR activation.

This study shows that membrane association stabilizes suboptimal membrane proteins like IAV M2, preventing premature degradation and enhancing biogenesis efficiency.

This study shows that the influenza A virus M2 viroporin can use multiple membrane insertion pathways, including EMC and Oxa1-family translocons, ensuring robust viral infection.

This study shows that the EMC3 subunit is critical for lipid droplet homeostasis in mice and Drosophila, with loss of EMC3 causing triglyceride storage defects and reduced FITM2 levels.

This study identifies a phosphorylation-independent 14-3-3 interaction site in iRhom2's N-terminus that regulates ADAM17 activity and shows how mutations in this region cause different pathological outcomes.

This study shows that iTAP regulates ADAM17 activity, affecting inflammation, epithelial repair, and tumor growth in mice without causing widespread ADAM17 loss effects.