Emma Burbridge

Rhomboid protease RHBDL2 is a calcium-activated suppressor of EGFR signalling in keratinocytes.

This study identifies RHBDL2 as a calcium-activated rhomboid protease that suppresses EGFR signaling in keratinocytes by shedding its ectodomain, thereby limiting cell migration and invasion.

A critical role for the ER Membrane Complex (EMC) in lipid droplet homeostasis

This study shows that the EMC3 subunit is critical for lipid droplet homeostasis in mice and Drosophila, with loss of EMC3 causing triglyceride storage defects and reduced FITM2 levels.

The ADAM17 sheddase complex regulator iTAP modulates inflammation, epithelial repair, and tumor growth

This study shows that iTAP regulates ADAM17 activity, affecting inflammation, epithelial repair, and tumor growth in mice without causing widespread ADAM17 loss effects.