Modulation of the 14-3-3σ/C-RAF autoinhibited complexby molecular glues
Markella Konstantinidou, Holly R. Vickery, Marloes A. M. Pennings, Johanna M. Virta, Shu Luo, Emira J. Visser, Sean D. Bannier, Mrudula Srikanth, Sabine Z. Cismoski, Lucy C. Young, Maxime C. M. van den Oetelaar, Frank P. McCormick, Christian Ottmann, Luc Brunsveld, Michelle R. Arkin
This paper designs molecular glues that stabilize the 14-3-3/C-RAF autoinhibited complex, showing selectivity and functional effects in biophysical and cell assays.
Journal of the American Chemical Society · Jan 30, 2026Peer-reviewedBiochemistry