Author

Holly R. Vickery

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

Johanna M. VirtaiD· 2 shared Markella KonstantinidouiD· 2 shared Michelle R. ArkiniD· 2 shared Christian OttmanniD· 1 shared Emira J. VisseriD· 1 shared Frank P. McCormickiD· 1 shared Luc BrunsveldiD· 1 shared Lucy C. YoungiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Johanna M. VirtaORCID

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2 papers

Recent·Most cited

BiochemistryJournal of the American Chemical SocietyPeer-reviewedJan 30, 2026

Modulation of the 14-3-3σ/C-RAF autoinhibited complexby molecular glues

Markella Konstantinidou, Holly R. Vickery, Marloes A. M. Pennings…·Michelle R. Arkin

This paper designs molecular glues that stabilize the 14-3-3/C-RAF autoinhibited complex, showing selectivity and functional effects in biophysical and cell assays.

6 citationstop 2%

deep learningdrug response / drug discovery

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Cell BiologybioRxivDec 31, 2023

Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues

Holly R. Vickery, Johanna M. Virta, Markella Konstantinidou, Michelle R. Arkin

The paper develops a NanoBRET assay to evaluate molecular glues targeting 14-3-3σ client proteins in living cells, showing EC50 values consistent with in vitro measurements.

DOI 10.1016/j.slasd.2024.100165

protein structureexperimental assay

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