VEGFA critically controls neurovascular invasion and chronic low back pain during intervertebral disc degeneration
RG Potter, Hong Joo Moon, Sade W. Clayton, Remy E. Walk, Addison L. Liefer, Liufang Jing, Evan G. Buettmann, Jennifer A. McKenzie, Alec T. Beeve, Erica L. Scheller, Matthew J. Silva, Amber N. Stratman, Lori A. Setton, Munish C. Gupta, Simon Y. Tang
This study shows that VEGFA drives neurovascular invasion in degenerating intervertebral discs and contributes to chronic low back pain, with its inhibition preventing pain behaviors.
bioRxiv · Jun 3, 2025 · PreprintNeuroscience