Author
Broad Institute
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Jeong Min Lee, Jing Zeng, Pengpeng Liu…·Celia A. Schiffer
This study develops stabilized Cas-embedded base editors (sCE_CBEs) that enable efficient and accurate C-to-T editing with minimal off-target effects in hematopoietic stem and progenitor cells.
Jing Zeng, My Anh Nguyen, Pengpeng Liu…·Daniel E. Bauer
This study shows that gene editing of HSCs without ex vivo culture reduces genotoxicity while maintaining therapeutic efficacy for beta-hemoglobinopathy treatment.
Jiecong Lin, My Anh Nguyen, Linda Yingqi Lin…·Daniel E. Bauer
The paper develops ABSOLVE-seq to assess genome editing off-targets linked to genetic variants using primary cells and sequencing, enabling evaluation of human genetic diversity's impact on gene editing specificity.
Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin…·Luca Pinello
The paper develops CRISPRme, a tool that integrates genetic diversity data to assess off-target risks of gene editing, finding allele-specific off-target effects in clinical gRNAs.