Author

Archana Verma

Broad InstitutePrimary ORCID profile (0000-0001-9273-8958 · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Archana VermaiD3 papers · National Dairy Research Institute

Biology Disciplines

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1 Research Focus:software / tool· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Daniel E. BaueriD· 3 shared Christian BrendeliD· 2 shared Danilo PelliniD· 2 shared Jing ZengiD· 2 shared Kendell ClementiD· 2 shared Linda Yingqi LiniD· 2 shared Luca PinelloiD· 2 shared Lucas Ferreira da SilvaiD· 2 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Daniel E. BauerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Sébastien Levesque, Linda Yingqi Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola R. Neri, Tolulope O. Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, , Daniel E. Bauer

This study shows that gene editing of HSCs without ex vivo culture reduces genotoxicity while maintaining therapeutic efficacy for beta-hemoglobinopathy treatment.

Cell stem cell · Dec 12, 2024Peer-reviewedGenetics

Scalable assessment of genome editing off-targets associated with genetic variants

Jiecong Lin, My Anh Nguyen, Linda Yingqi Lin, Jing Zeng, Archana Verma, Nola R. Neri, Lucas Ferreira da Silva, Adele Mucci, Scot A. Wolfe, Kit L. Shaw, Kendell Clement, Christian Brendel, Luca Pinello, Danilo Pellin, Daniel E. Bauer

The paper develops ABSOLVE-seq to assess genome editing off-targets linked to genetic variants using primary cells and sequencing, enabling evaluation of human genetic diversity's impact on gene editing specificity.

bioRxiv · Jul 24, 2024 · PreprintGenomics

Nucleotide metabolism constrains prime editing in hematopoietic stem and progenitor cells

Sébastien Levesque, Archana Verma, Daniel E. Bauer

This study shows that nucleotide metabolism limits prime editing efficiency in HSPCs and that deoxynucleoside supplementation and Vpx-mediated SAMHD1 degradation enhance it.

bioRxiv · Oct 22, 2023 · PreprintGenetics