BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III
Brandon Chen, Drew C. Stark, Pankaj V. Jadhav, Theophilus M. Lynn-Nguyen, Benjamin S. Halligan, Nicholas J. Rossiter, Nicole Sindoni, Myunsun Shin, Joao A. Paulo, Matthew Chang, Imhoi Koo, Sergei Koshkin, Sanjana Eyunni, Paolo Ronchi, Michelle T. Paulsen, , Yatrik M. Shah
The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.
bioRxiv · Feb 2, 2024 · PreprintCell Biology