Brandon Chen

Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death

This study identifies a heme-SDH-CoQ axis that helps colorectal cancer cells resist iron-induced oxidative stress and cell death.

A lipid metabolism defect is an underlying contributor to Diamond Blackfan anemia syndrome

The paper identifies a lipid metabolism defect as a contributor to variable anemia in Diamond Blackfan anemia syndrome using a murine model and transcriptomic analysis.

H2S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes

This study shows that chronic hydrogen sulfide exposure alters mitochondrial structure and function in human cells by disrupting cristae and respiratory supercomplexes.