Tumor Necrosis Factor Receptor Signaling Modulates Carcinogenesis in a Mouse Model of Breast Cancer
L. He, K. Bhat, S. Duhacheck-Muggy, A. Ioannidis, L. Zhang, N. T. Nguyen, N. A. Moatamed, F. Pajonk
This study shows that reducing TNFR2 signaling in mice increases breast cancer incidence and aggressiveness, suggesting TNFR2 agonists could help prevent breast cancer in high-risk populations.
bioRxiv · Mar 12, 2020Cancer Biology