R. Damoiseaux

Dynamic regulation of single-cell contractile heterogeneity in the human trabecular meshwork

This study quantifies single-cell contractility in human trabecular meshwork cells under various conditions and finds that contractility is context-dependent, shaped by both extracellular and intracellular factors.

High Throughput Screening with a Primary Human Mucociliary Airway Model Identifies a Small Molecule with Anti-SARS-CoV-2 Activity

This study uses a primary human stem cell-based airway model to screen 2100 compounds and identifies a small molecule effective against SARS-CoV-2 and its Omicron variant.

Development of a LRRC15-Targeted Radio-Immunotheranostic Approach to Deplete Pro-tumorigenic Mechanisms and Immunotherapy Resistance

This paper develops a radio-theranostic approach targeting LRRC15 to image and treat cancer, showing tumor reduction and reversal of immunotherapy resistance.

Comparative Analysis of Molecular Pathogenic Mechanisms and Antiviral Development Targeting Old and New World Hantaviruses

This study compares molecular mechanisms and antiviral targets of Old and New World hantaviruses using human cell models and identifies potential therapeutic compounds.

FLECS Technology for High-Throughput Screening of Hypercontractile Cellular Phenotypes in Fibrosis: A Function-First Approach to Anti-Fibrotic Drug Discovery

This study develops a high-throughput screening platform to identify anti-fibrotic compounds by quantifying myofibroblast contractility in response to TGF-β1.

NSC95397 is a Novel HIV-1 Latency Reversing Agent

This study identifies NSC95397 as a novel HIV-1 latency reversing agent that synergizes with existing LRAs and targets previously unrecognized pathways.

Identification of a Papain-Like Protease Inhibitor with Potential for Repurposing in Combination with an Mpro Protease Inhibitor for Treatment of SARS-CoV-2

The paper identifies eltrombopag as a PLpro inhibitor that can be repurposed for SARS-CoV-2 treatment, effective in combination with Mpro inhibitors.

Assessing Functional Androgen Receptor Pathway Activity in Response to Radiotherapy Using hK2-targeted PET Imaging

This study evaluates if [89Zr]11B6-PET can detect EBRT-induced AR pathway activation in PCa using hK2 as a biomarker.

Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2

The paper identifies amyloid-forming segments in SARS-CoV-2 Nucleoprotein and designs peptide inhibitors based on their atomic structures to target Covid-19.

DUSP7 Regulates the Activity of ERK2 to PromoteProper Chromosome Alignment During Cell Division

This study shows DUSP7 regulates ERK2 activity to ensure proper chromosome alignment during cell division, preventing aneuploidy and tumorigenesis.

PSA-targeted Alpha-, Beta- and Positron Emitting Immuno-Theranostics in Murine Prostate Cancer Models and Non-Human Primates

This paper evaluates the theranostic potential of hu5A10 in prostate cancer models, showing it reduces tumor burden and prolongs survival.

Massively parallel encapsulation of single cells with structured microparticles and secretion-based flow sorting

This paper introduces a method to sort single cells based on secreted products using microparticles, enabling high-throughput screening of cell function.

Genetic signature of prostate cancer resistant to optimized hK2 targeted alpha-particle therapy

The paper evaluates enhanced alpha-radioimmunotherapy for prostate cancer using [225Ac]hu11B6-IgG3 and analyzes genomic changes in resistant tumors.

A simple high-throughput approach identifies actionable drug responses in patient-derived tumor organoids

This paper introduces a high-throughput method for drug screening using tumor organoids and identifies effective drugs for ovarian cancer within a week of surgery.