M. F. Pignataro

CRISPR/Cas9-based edition of frataxin gene in Dictyostelium discoideum for Friedreich's Ataxia disease modeling

This paper develops a Dictyostelium discoideum model for Friedreich's Ataxia by editing the fxn locus and assessing the effects of a human variant.

Selection of Synthetic Proteins to Modulate the Human Frataxin Function

This study selects a synthetic protein, Affi_224, that modulates frataxin function with nanomolar affinity, showing potential for therapeutic applications in Friedreichs Ataxia.

Production of a Highly Immunogenic Antigen from SARS-CoV-2 by Covalent Coupling of the Receptor Binding Domain of Spike Protein to a Multimeric Carrier

This paper shows that coupling multiple SARS-CoV-2 RBD units to a multimeric carrier protein enhances immune response, leading to higher neutralizing antibody titers.

Structural and Functional Comparison of SARS-CoV-2-Spike Receptor Binding Domain Produced in Pichia pastoris and Mammalian Cells

This study compares the structural and functional properties of SARS-CoV-2 Spike RBD produced in yeast and mammalian cells, finding similar stability but greater heterogeneity in yeast-produced RBD.