Novel MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine
L. Fets, N. Bevan, P. M. Nunes, S. Campos, M. Silva dos Santos, E. B. Sherriff, J. I. MacRae, D. House, D. Anastasiou
The paper designs and characterizes MOG analogues to study MCT2 pharmacophore, KG biology, and cellular effects of NOG, showing compounds that inhibit PHDs without cytotoxicity.
bioRxiv · Mar 15, 2021Biochemistry