Location bias contributes to functionally selective responses of biased CXCR3 agonists
D. S. Eiger, N. Boldizsar, C. C. Honeycutt, J. Gardner, S. Kirchner, C. Hicks, I. Choi, U. Pham, K. Zheng, A. Warman, J. Smith, J. Zhang, S. Rajagopal
The paper shows that biased CXCR3 agonists produce different signaling outcomes based on subcellular location, with endosomal signaling playing a key role in biased activation.
bioRxiv · Jan 13, 2022Biochemistry