J. Gardner

An off-lattice discrete model to characterise filamentous yeast colony morphology

The paper uses an off-lattice agent-based model and experimental data to show that budding mechanisms and nutrient concentration drive filamentous yeast colony morphology.

ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins

The paper identifies novel GPCR interacting proteins independent of G proteins and β-arrestins using proximity labeling in cells lacking β-arrestin.

Commensal myeloid crosstalk in neonatal skin regulates cutaneous type 17 inflammation

This study shows that commensal microbes in neonatal skin promote immune homeostasis by regulating monocyte accumulation and IL-17A production by T cells.

Phosphorylation barcodes direct biased chemokine signaling at CXCR3

The paper shows that CXCR3 chemokines use different phosphorylation barcodes to activate distinct signaling pathways, leading to varied physiological outcomes.

Subcellular localization of GPCR kinases differentially modulate biased signaling at CXCR3

The paper shows GRKs translocate to endosomes after CXCR3 activation, with ligand-specific GRK recruitment affecting biased signaling.

Location bias contributes to functionally selective responses of biased CXCR3 agonists

The paper shows that biased CXCR3 agonists produce different signaling outcomes based on subcellular location, with endosomal signaling playing a key role in biased activation.

Metallothionein 3-zinc axis suppresses caspase-11 inflammasome activation and impairs antibacterial immunity

The paper identifies MT3 as a negative regulator of caspase-11 inflammasome activation in macrophages, which suppresses antibacterial immunity.

Using GC content to compare recombination patterns on the sex chromosomes and autosomes of the guppy, Poecilia reticulata, and its close outgroup species

The paper uses GC content to infer recombination patterns in guppy chromosomes, finding high recombination rates near chromosome ends and no evidence of distinct XY recombination patterns.

Environmental Exposures Influence Nasal Microbiome Composition in a Longitudinal Study of Division I Collegiate Athletes

This study examines how environmental exposures and exercise affect the nasal microbiome of female collegiate athletes over time.

Sexually dimorphic recombination can facilitate the establishment of sexually antagonistic polymorphisms in guppies

The paper investigates recombination patterns in guppies and finds male-specific recombination suppression that may facilitate sexually antagonistic polymorphisms.