Author

D. S. Eiger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:imaging· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

J. Gardner· 4 shared S. Rajagopal· 4 shared C. Hicks· 3 shared I. Choi· 3 shared U. Pham· 3 shared A. Warman· 2 shared K. Zheng· 2 shared A. Chundi· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersBiochemistry

J. Gardner

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4 papers

Recent·Most cited

ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins

C. Hicks, J. Gardner, D. S. Eiger, N. Camarda, U. Pham, S. Dhar, H. Rodriguez, A. Chundi, S. Rajagopal

The paper identifies novel GPCR interacting proteins independent of G proteins and β-arrestins using proximity labeling in cells lacking β-arrestin.

bioRxiv · Jan 27, 2024 · PreprintBiochemistry

Phosphorylation barcodes direct biased chemokine signaling at CXCR3

D. S. Eiger, J. S. Smith, T. Shi, T. M. Stepniewski, C.-F. Tsai, C. Honeycutt, N. Boldiszar, J. Gardner, C. D. Nicora, A. M. Moghieb, K. Kawakami, I. Choi, K. Zheng, A. Warman, P. Alagesan, , S. Rajagopal

The paper shows that CXCR3 chemokines use different phosphorylation barcodes to activate distinct signaling pathways, leading to varied physiological outcomes.

bioRxiv · Mar 14, 2023Biochemistry

Subcellular localization of GPCR kinases differentially modulate biased signaling at CXCR3

J. Gardner, D. S. Eiger, C. Hicks, I. Choi, U. Pham, S. Rajagopal

The paper shows GRKs translocate to endosomes after CXCR3 activation, with ligand-specific GRK recruitment affecting biased signaling.

bioRxiv · Jul 11, 2022 · PreprintBiochemistry

Location bias contributes to functionally selective responses of biased CXCR3 agonists

D. S. Eiger, N. Boldizsar, C. C. Honeycutt, J. Gardner, S. Kirchner, C. Hicks, I. Choi, U. Pham, K. Zheng, A. Warman, J. Smith, J. Zhang, S. Rajagopal

The paper shows that biased CXCR3 agonists produce different signaling outcomes based on subcellular location, with endosomal signaling playing a key role in biased activation.

bioRxiv · Jan 13, 2022Biochemistry