Author

N. G. Posnack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Pharmacology & Toxicology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:electrophysiology· 5 Organism:rat· 5 Research Focus:host-pathogen & immune response· 4 Assay:imaging· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Organism:human· 2

Frequent Co-Authors

D. Guerrelli· 4 shared L. Swift· 4 shared M. Ramadan· 3 shared M. Reilly· 3 shared R. Jaimes· 3 shared A. Roberts· 2 shared D. McCullough· 2 shared K. Haq· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersPharmacology & Toxicology

D. Guerrelli

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Author profile →

8 papers

Recent·Most cited

Electroanatomical Adaptations in the Guinea Pig Heart from Neonatal to Adulthood

K. T. Haq, K. McLean, S. Salameh, L. M. Swift, N. G. Posnack

This study examines electroanatomical changes in guinea pig hearts from neonatal to adult stages, finding age-related differences in conduction velocity, action potential duration, and excitation-contraction coupling.

bioRxiv · Jan 26, 2024Physiology

KairoSight-3.0: Validated Optical Mapping Software to Characterize Cardiac Electrophysiology, Excitation-Contraction Coupling, and Alternans

K. Haq, A. Roberts, F. Berk, S. Allen, L. Swift, N. G. Posnack

KairoSight-3.0 is a software package for semi-automated analysis of cardiac optical mapping data, providing accurate measurements of electrophysiology, calcium transients, and excitation-contraction coupling.

Journal of Molecular and Cellular Cardiology Plus · Sep 1, 2023Peer-reviewedPhysiology

Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexylphthalate (DEHP)

L. M. Swift, A. Roberts, J. Pressman, D. Guerrelli, S. Allen, K. Haq, J. Reisz, A. D'Alessandro, N. G. Posnack

This study shows DEHP exposure impairs cardiac function in rats, with dose- and time-dependent effects on conduction and rhythm.

bioRxiv · May 22, 2023 · PreprintPharmacology & Toxicology

The Impact of Chronic Phthalate Exposure on Rodent Anxiety and Cognition

Z. Yu, L. Iyer, A. P. Swiercz, E. Paronett, M. Ramadan, P. J. Marvar, N. G. Posnack

This study examines the effects of chronic phthalate exposure on rodent anxiety and cognition, finding increased anxiety-like behaviors and HPA-axis dysregulation without cognitive impairment.

bioRxiv · Apr 13, 2023Pharmacology & Toxicology

Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology and potentially safer for use in medical products, as compared to bisphenol A

T. Prudencio, L. Swift, D. Guerrelli, B. Cooper, M. Reilly, N. Ciccarrelli, J. Sheng, R. Jaimes, N. G. Posnack

This study compares the effects of bisphenol analogues on cardiac electrophysiology, finding BPA and BPF inhibit ion channels more than BPS.

Toxicological Sciences · Jul 8, 2021Peer-reviewedPharmacology & Toxicology

Potential consequences of the red blood cell storage lesion on cardiac electrophysiology

M. Reilly, C. Bruno, T. Prudencio, N. Ciccarelli, D. Guerrelli, R. Nair, M. Ramadan, N. Luban, N. G. Posnack

This study shows that older red blood cell units affect cardiac electrophysiology, likely due to biochemical changes, including hyperkalemia, and highlights risks for certain patient groups.

bioRxiv · May 22, 2020Physiology

Lights, Camera, Path Splitter: A New Approach for Truly Simultaneous Dual Optical Mapping of the Heart with a Single Camera

R. Jaimes, D. McCullough, B. Siegel, L. Swift, J. Hiebert, D. McInerney, N. G. Posnack

The paper introduces a method to simultaneously map cardiac voltage and calcium using a single camera and path splitter, achieving high spatiotemporal resolution in whole heart preparations.

bioRxiv · Jul 24, 2019Bioengineering

Age-dependent changes in electrophysiology and calcium handling: implications for pediatric cardiac research

L. Swift, M. Burke, D. Guerrelli, M. Ramadan, M. Reilly, D. McCullough, A. Chaluvadi, C. Mulvany, R. Jaimes, N. G. Posnack

This study examines age-related changes in cardiac electrophysiology and calcium handling in rats, finding slowed conduction, prolonged action potentials, and altered gene expression in immature hearts.

bioRxiv · Jun 3, 2019Physiology