Author

L. Swift

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Physiology· 3 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:imaging· 3 Organism:mouse· 3 Organism:rat· 3 Assay:electrophysiology· 2 Organism:human· 2

Frequent Co-Authors

N. G. Posnack· 4 shared D. Guerrelli· 3 shared M. Reilly· 3 shared R. Jaimes· 3 shared C. Mulvany· 2 shared D. McCullough· 2 shared M. Ramadan· 2 shared A. Benedikt· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPhysiology

N. G. Posnack

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A novel genetic fluorescent reporter to visualize mitochondrial nucleoids

J. O. David, J. Deng, L. Swift, M. Zaman, A. Sharma, D. Bureik, F. Padovani, A. Benedikt, F. Shahhosseini, A. Jaiswal, A. Mohan, C. Brideau, S. Grewal, K. M. Schmoller, P. Colarusso, T. E. Shutt

The paper introduces a genetic fluorescent reporter, mt-HI-NESS, to visualize mitochondrial nucleoids in live cells without affecting mtDNA replication or expression.

bioRxiv · Oct 23, 2023 · PreprintCell Biology

KairoSight-3.0: Validated Optical Mapping Software to Characterize Cardiac Electrophysiology, Excitation-Contraction Coupling, and Alternans

K. Haq, A. Roberts, F. Berk, S. Allen, L. Swift, N. G. Posnack

KairoSight-3.0 is a software package for semi-automated analysis of cardiac optical mapping data, providing accurate measurements of electrophysiology, calcium transients, and excitation-contraction coupling.

bioRxiv · May 1, 2023Physiology

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

T. Brevini, M. Maes, G. J. Webb, W. T. H. Gelson, S. Forrest, P. Mlcochova, S. Dillon, S. Varankar, M. Darvish-Damavandi, V. L. Mulcahy, R. E. Kuc, T. L. Williams, V. Galanakis, M. Vila-Gonzalez, O. C. Tysoe, , F. Sampaziotis

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

bioRxiv · Jun 6, 2021 · PreprintMicrobiology

Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology and potentially safer for use in medical products, as compared to bisphenol A

T. Prudencio, L. Swift, D. Guerrelli, B. Cooper, M. Reilly, N. Ciccarrelli, J. Sheng, R. Jaimes, N. G. Posnack

This study compares the effects of bisphenol analogues on cardiac electrophysiology, finding BPA and BPF inhibit ion channels more than BPS.

bioRxiv · Feb 16, 2021Pharmacology & Toxicology

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

H. T. Baddock, S. Brolih, Y. Yosaatmadja, M. Ratnaweera, M. Bielinski, L. Swift, A. Cruz-Migoni, G. M. Morris, C. J. Schofield, O. Gileadi, P. J. McHugh

This study characterizes the SARS-CoV-2 nsp14-nsp10 complex as an RNA nuclease, identifies its role in genome stability, and discovers inhibitors targeting this complex.

bioRxiv · Aug 13, 2020 · PreprintBiochemistry

Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease

J. Romanowicz, Z. Dhari, D. Guerrelli, C. Mulvany, M. Reilly, L. Swift, N. Vasandani, M. Ramadan, N. Ishibashi, N. Posnack

This study examines the effects of chronic perinatal hypoxia on cardiac development in a mouse model of cyanotic congenital heart disease, finding persistent electrophysiological and functional impairments.

bioRxiv · May 28, 2020Physiology

Lights, Camera, Path Splitter: A New Approach for Truly Simultaneous Dual Optical Mapping of the Heart with a Single Camera

R. Jaimes, D. McCullough, B. Siegel, L. Swift, J. Hiebert, D. McInerney, N. G. Posnack

The paper introduces a method to simultaneously map cardiac voltage and calcium using a single camera and path splitter, achieving high spatiotemporal resolution in whole heart preparations.

bioRxiv · Jul 24, 2019Bioengineering

Age-dependent changes in electrophysiology and calcium handling: implications for pediatric cardiac research

L. Swift, M. Burke, D. Guerrelli, M. Ramadan, M. Reilly, D. McCullough, A. Chaluvadi, C. Mulvany, R. Jaimes, N. G. Posnack

This study examines age-related changes in cardiac electrophysiology and calcium handling in rats, finding slowed conduction, prolonged action potentials, and altered gene expression in immature hearts.

bioRxiv · Jun 3, 2019Physiology