S. Allen

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

The paper develops a framework for classifying variants of reduced penetrance in cancer susceptibility genes to improve variant interpretation consistency.

EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake

This study shows EPAS1 reduces atherosclerosis at disturbed flow sites by promoting endothelial fatty acid uptake and metabolism, which is suppressed in obesity through triglyceride-PHD3 pathway.

KairoSight-3.0: Validated Optical Mapping Software to Characterize Cardiac Electrophysiology, Excitation-Contraction Coupling, and Alternans

KairoSight-3.0 is a software package for semi-automated analysis of cardiac optical mapping data, providing accurate measurements of electrophysiology, calcium transients, and excitation-contraction coupling.

Arylamine N-acetyltransferase-1 reveals a subpopulation of ALS patients with altered metabolic capacity

The paper identifies a subpopulation of ALS patients with altered metabolic capacity linked to NAT1 activity, showing higher metabolic indices and faster disease progression.

Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexylphthalate (DEHP)

This study shows DEHP exposure impairs cardiac function in rats, with dose- and time-dependent effects on conduction and rhythm.

Endothelial-specific reduction in Arf6 impairs insulin-stimulated vasodilation and skeletal muscle blood flow resulting in systemic insulin resistance

This study shows that reducing Arf6 in endothelial cells impairs insulin-stimulated vasodilation and causes systemic insulin resistance.

Engineering Nanowires in Bacteria to Elucidate Electron Transport Structural Functional Relationships

This paper engineers type-IV pilus proteins in bacteria to study structure-function relationships in electron transport, using atomic force microscopy and electrochemical methods to analyze conductivity and pili structure.

Causes, temporal trends and the effects of urbanisation on admissions of wild raptors to rehabilitation centres in England and Wales

This study analyzes raptor admissions to wildlife rehabilitation centers in England and Wales, identifying causes of morbidity/mortality, temporal trends, and urbanization effects from 2001-2019.

AusTraits: a curated plant trait database for the Australian flora

AusTraits is a curated plant trait database for the Australian flora, containing 937243 trait-by-taxa combinations across 375 traits and 29230 taxa.

Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability

This paper shows subcutaneous rapamycin delivery via nanocarriers changes its immunosuppressive mechanism, improving islet graft survival in a transplant model.

The Combination of Morphology and Surface Chemistry Defines the Biological Identity of Nanocarriers in Human Blood

The paper shows that both the surface chemistry and morphology of nanocarriers influence their protein corona composition and immune interactions in human blood.

LipidFinder 2.0: advanced informatics pipeline for lipidomics discovery applications

LipidFinder 2.0 improves lipidomics analysis with new modules for artefact filtering, isotope deletion, and FDR assessment, showing better performance than existing tools.

Novel mTORC1 inhibitors kill Glioblastoma stem cells

This paper identifies novel mTORC1 inhibitors that effectively kill GBM stem cells and shows their potential as adjuvant therapy when combined with temozolomide.

Global shortfalls in extinction risk assessments for endemic flora

The paper assesses global extinction risk for endemic plant species, finding that 67% of country-based endemic species lack risk assessments, despite urgent conservation needs.

Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

This study characterizes treatment-induced high-grade gliomas (TIHGGs) through molecular profiling, identifying distinct subgroups and potential therapeutic targets.

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.