Author

N. H. Patterson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:imaging· 4 Assay:metabolomics· 2 Assay:spatial transcriptomics· 2 Approach:deep learning· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

J. M. Spraggins· 4 shared A. B. Fogo· 3 shared E. S. Rivera· 3 shared R. M. Caprioli· 3 shared A. Kotnala· 2 shared C. A. Curcio· 2 shared D. M. Anderson· 2 shared E. K. Neumann· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersBiochemistry

J. M. Spraggins

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Author profile →

6 papers

Recent·Most cited

Revealing In Situ Molecular Profiles of Glomerular Cell Types and Substructures with Integrated Imaging Mass Spectrometry and Multiplexed Immunofluorescence Microscopy

A. B. Esselman, F. A. Moser, L. Tideman, L. G. Migas, K. V. Djambazova, M. E. Colley, E. L. Pingry, N. H. Patterson, M. A. Farrow, H. Yang, A. B. Fogo, M. de Caestecker, R. Van de Plas, J. M. Spraggins

This paper integrates MALDI IMS and MxIF microscopy to analyze lipid and molecular profiles of glomerular cell types and substructures in human kidney tissue.

bioRxiv · Feb 21, 2024 · PreprintBiochemistry

Omics Scale Quantitative Mass Spectrometry Imaging of Lipids in Brain Tissue using a Multi-Class Internal Standard Mixture

M. Vandenbosch, S. M. Mutuku, M. J. Q. Mantas, N. H. Patterson, T. Hallmark, M. Claesen, R. M. A. Heeren, N. G. Hatcher, N. Verbeeck, K. Ekroos, S. R. Ellis

This paper introduces a method for quantitative mass spectrometry imaging of lipids in brain tissue using a multi-class internal standard mixture, revealing absolute lipid concentrations across multiple lipid classes.

bioRxiv · Jun 21, 2023Biochemistry

A Lipid Atlas of the Human Kidney

M. A. Farrow, L. E. M. Tideman, E. K. Neumann, L. G. Migas, N. H. Patterson, M. E. Colley, J. L. Allen, E. L. Pingry, M. Dufresne, H. Yang, M. Brewer, E. S. Rivera, C. E. Romer, K. Djambazova, K. Sharman, , J. M. Spraggins

The paper constructs a spatio-molecular lipid atlas of the human kidney using multimodal imaging and machine learning, revealing lipid profile variations related to sex and BMI.

bioRxiv · Apr 7, 2022Biochemistry

Tissue fixation effects on human retinal lipid analysis by MALDI imaging and LC-MS/MS technologies

A. Kotnala, D. M. Anderson, N. H. Patterson, L. S. Cantrell, J. D. Messinger, C. A. Curcio, K. L. Schey

This study evaluates how tissue fixation affects lipid analysis in human retina using MALDI-IMS and LC-MS/MS, finding that fixation alters lipid signals but preserves major lipid classes.

bioRxiv · Apr 29, 2021Biochemistry

Highly Multiplexed Immunofluorescence of the Human Kidney using Co-Detection by Indexing (CODEX)

E. K. Neumann, E. S. Rivera, N. H. Patterson, J. L. Allen, M. Brewer, M. deCaestecker, A. B. Fogo, R. M. Caprioli, J. M. Spraggins

This paper applies CODEX multiplexed immunofluorescence to visualize 23 antigens in human kidney tissue, identifying major cell types and substructures with high resolution.

bioRxiv · Dec 4, 2020Cell Biology

Lipid Landscape of the Human Retina and Supporting Tissues Revealed by High Resolution Imaging Mass Spectrometry

D. M. Anderson, J. D. Messinger, N. H. Patterson, E. S. Rivera, A. Kotnala, J. M. Spraggins, R. M. Caprioli, C. A. Curcio, K. L. Schey

This study uses high-resolution imaging mass spectrometry to map lipid distributions in human retina and supporting tissues at laminar, cellular, and sub-cellular levels.

bioRxiv · Apr 8, 2020Biochemistry