R. M. A. Heeren

This paper introduces a method for quantitative mass spectrometry imaging of lipids in brain tissue using a multi-class internal standard mixture, revealing absolute lipid concentrations across multiple lipid classes.

This study uses stable-isotope labelled fatty acids to reveal distinct metabolic fates of exogenous and de novo synthesized fatty acids in cancer cells, showing compartmentalized lipid metabolism.

This study identifies sphingolipid composition as a driver of fibroblast heterogeneity and state transitions using single-cell lipidomics and transcriptomics.

The paper uses mass spectrometry imaging with isotopic tracers to visualize phosphatidylcholine metabolism in mouse lungs, revealing metabolic processes and acyl chain remodeling.