K. L. Schey

Proteome Remodeling of the Eye Lens at 50 Years Identified with Data-Independent Acquisition

This study uses DIA mass spectrometry to analyze age-related proteome changes in human lens tissue, revealing significant remodeling at 50 years linked to oxidative stress and ARNC formation.

Lens aquaporin-5 inserts into bovine fiber cell plasma membranes through mitochondria-associated lysosome secretion

This study maps AQP5 expression in bovine lens, identifies its vesicular trafficking, and shows lysosome secretion as a novel mechanism for AQP5 plasma membrane insertion.

Data Independent Acquisition Mass Spectrometry of the Human Lens Enhances Spatiotemporal Measurement of Fiber Cell Aging

This study uses DIA mass spectrometry to analyze the human lens proteome, revealing age-related changes in protein composition and function across different fiber cell regions.

Tissue fixation effects on human retinal lipid analysis by MALDI imaging and LC-MS/MS technologies

This study evaluates how tissue fixation affects lipid analysis in human retina using MALDI-IMS and LC-MS/MS, finding that fixation alters lipid signals but preserves major lipid classes.

Spatially-Resolved Proteomic Analysis of the Lens Extracellular Diffusion Barrier

This study identifies molecular components contributing to the lens extracellular diffusion barrier through proteomic analysis of bovine lens cortex regions.

Functional cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

This study identifies human monoclonal antibodies that neutralize HeV and NiV by targeting distinct antigenic sites on the receptor binding protein and demonstrates their cooperative binding and synergistic therapeutic effects.

Changes to zonular tension alters the subcellular distribution of AQP5 in regions of influx and efflux of water in the rat lens.

This study examines how changes in zonular tension affect the subcellular distribution of AQP5 in rat lens water influx and efflux zones, finding that AQP5 shifts from membranous to cytoplasmic under reduced tension.

Localization of the Lens Intermediate Filament Switch by Imaging Mass Spectrometry

This study uses imaging mass spectrometry to map the spatial localization of cytoskeletal proteins in the bovine lens, revealing an intermediate filament switch and posttranslational modifications in the lens cortex.

Lipid Landscape of the Human Retina and Supporting Tissues Revealed by High Resolution Imaging Mass Spectrometry

This study uses high-resolution imaging mass spectrometry to map lipid distributions in human retina and supporting tissues at laminar, cellular, and sub-cellular levels.