Author

N. Hirani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:C. elegans· 3 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

K. Ng· 4 shared T. Bland· 4 shared N. W. Goehring· 3 shared A. S. Mirchandani· 2 shared C. C. Bain· 2 shared J. Borrego-Pinto· 2 shared S. J. Jenkins· 2 shared A. J. Simpson· 1 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersCell Biology

K. Ng

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Author profile →

6 papers

Recent·Most cited

Optimized dimerization of the PAR-2 RING domain drives cooperative and selective membrane recruitment for robust feedback-driven cell polarization

T. Bland, N. Hirani, D. Briggs, R. Rossetto, K. Ng, N. Q. McDonald, D. Zwicker, N. W. Goehring

This study shows that optimized dimerization of the PAR-2 RING domain enables cooperative and selective membrane recruitment, enhancing robustness and responsiveness in cell polarization.

bioRxiv · Aug 10, 2023 · PreprintCell Biology

Cleavage furrow-directed cortical flows bias mechanochemical pathways for PAR polarization in the C. elegans germ lineage

K. Ng, N. Hirani, T. Bland, J. B. Pinto, N. W. Goehring

The paper investigates PAR polarization in C. elegans germline cells, finding that cleavage furrow-directed cortical flows drive symmetry breaking similar to zygote mechanisms.

bioRxiv · Dec 22, 2022Cell Biology

Design principles for selective polarization of PAR proteins by cortical flows

R. Illukkumbura, N. Hirani, J. Borrego-Pinto, T. Bland, K. Ng, L. Hubatsch, J. McQuade, R. Endres, N. Goehring

The paper shows that PAR protein segregation by cortical flows depends on membrane association stability rather than oligomer size, and demonstrates this through experiments and theory.

bioRxiv · Sep 5, 2022 · PreprintCell Biology

Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence

A. S. Mirchandani, S. J. Jenkins, C. C. Bain, H. Lawson, P. Coelho, F. Murphy, D. Griffith, A. Zhang, M. A. Sanchez-Garcia, L. Reyes, T. Morrison, S. Arienti, P. Sadiku, E. Watts, R. Dickinson, , S. Walmsley

This study shows hypoxia suppresses type I interferon signaling in ALI, leading to monocytopenia and unchecked inflammation, which can be mitigated by CSF1 administration.

bioRxiv · Mar 11, 2022 · PreprintCell Biology

SAIBR: A simple, platform-independent method for spectral autofluorescence correction

N. T. L. Rodrigues, T. Bland, J. Borrego-Pinto, K. Ng, N. Hirani, Y. Gu, S. Foo, N. W. Goehring

SAIBR corrects autofluorescence in imaging data using a simple, platform-independent method, enabling accurate quantification of weakly expressed proteins across diverse systems.

bioRxiv · Jan 19, 2022Cell Biology

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

J. McCowan, P. M. Kirkwood, F. Fercoq, W. T'Jonck, C. M. Mawer, R. Cunningham, A. S. Mirchandani, A. M. Hoy, G.-R. Jones, C. G. Hansen, N. Hirani, S. J. Jenkins, S. Henri, B. Malissen, S. R. Walmsley, , C. C. Bain

This study identifies EGR2 as essential for the identity and function of alveolar macrophages in health and tissue repair.

bioRxiv · May 6, 2021Immunology