Interferon-induced lysosomal membrane permeabilization and death cause cDC1-deserts in tumors.
E. Aerakis, A. Chatzigeorgiou, M.-M. Alvanou, M. Matthaiakaki-Panagiotaki, I. Angelidis, D. Koumadorakis, A. Galaras, P. Hatzis, D. Kerdidani, M. Makridakis, A. Vlahou, B. Malissen, S. Henri, M. Merad, M. Tsoumakidou
This study identifies interferon-induced lysosomal membrane permeabilization and death as mechanisms causing cDC1 scarcity in tumors, suggesting therapeutic strategies to enhance anti-tumor immunity.
bioRxiv · Mar 14, 2022 · PreprintImmunology