C. C. Bain

γδ T cells impair airway macrophage differentiation in lung adenocarcinoma

The paper identifies that CD27+ γδ T cells impair the differentiation of tumor-associated macrophages into airway macrophages in lung adenocarcinoma.

CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration following radiation-induced injury

This study identifies CSF1R-dependent macrophages as critical for epithelial regeneration after radiation-induced salivary gland injury.

Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence

This study shows hypoxia suppresses type I interferon signaling in ALI, leading to monocytopenia and unchecked inflammation, which can be mitigated by CSF1 administration.

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

This study identifies EGR2 as essential for the identity and function of alveolar macrophages in health and tissue repair.

High-dimensional profiling demonstrates complexity, tissue imprinting, and lineage-specific precursors within the mononuclear phagocyte compartment of the human intestine

The paper uses single-cell methods to explore the complexity of the mononuclear phagocyte compartment in the human intestinal lamina propria, identifying distinct subsets, site-specific signatures, and lineage-specific precursors.

Recruited macrophages that colonise the post-inflammatory peritoneal niche convert into functionally divergent resident cells

This study shows inflammation-elicited macrophages in the peritoneal cavity can adopt a resident-like identity but are functionally divergent due to environmental influences and time of residency.

Origin and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages.

This study shows that sex and age influence peritoneal macrophage behavior through bone marrow replenishment and microenvironment signals, affecting disease resistance.