Author

N. J. Gay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:Arabidopsis· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

M. C. Moncrieffe· 2 shared S. G. Soares· 2 shared A. L. V. Zorzetto-Fernandes· 1 shared A. Sardinha-Silva· 1 shared A. Sher· 1 shared C. D. Lopes· 1 shared C. F. Pinzan· 1 shared D. Jacot· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

M. C. Moncrieffe

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 10, 2022

Anterograde Trafficking of Toll-Like Receptors Requires the Cargo Sorting Adaptors TMED-2 and 7 and specific N-glycans

N. J. Gay, S. G. Soares, M. C. Moncrieffe…·M. F. Symmons

This study identifies TMED2 and TMED7 as cargo sorting adaptors required for TLR trafficking from the ER to Golgi, with specific N-glycans on TLR2 playing a role in this process.

DOI 10.1101/2022.10.10.511598

experimental assaycell signaling & trafficking

ImmunologybioRxivSep 6, 2021

Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti

Y. Saucereau, T. H. Wilson, M. C. , K. Tang…·M. Gangloff

The paper presents cryo-EM structures of Toll5A and Spaetzle1C complexes in Aedes aegypti, revealing their asymmetric interactions and distinct transcriptional roles in immune response.

DOI 10.1038/s41467-022-32690-6

Arabidopsiscryo-EM

ImmunologybioRxivJun 13, 2019

The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming

A. Sardinha-Silva, F. C. Mendonca-Natividade, C. F. Pinzan…·M. C. Roque-Barreira

This paper shows that Toxoplasma gondii microneme proteins MIC1 and MIC4 bind TLR2 and TLR4 N-glycans to activate innate immune responses and regulate infection outcomes.

DOI 10.1371/journal.ppat.1007871

mouseproteomics