C. F. Pinzan

Brilacidin, a novel antifungal agent against Cryptococcus neoformans

This paper identifies brilacidin as a novel antifungal agent effective against Cryptococcus neoformans, showing it reduces fungal survival in macrophages and potentiates existing antifungals.

Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus Aspergillus fumigatus

This study shows that brilacidin enhances ibrexafungerp's antifungal effect against Aspergillus fumigatus, including strains resistant to caspofungin.

Strain heterogeneity in a non-pathogenic fungus highlights factors contributing to virulence

This study examines strain variation in a non-pathogenic fungus, identifying factors linked to virulence differences across strains.

Milteforan, a promising veterinary commercial product against feline sporotrichosis

The paper shows milteforan, a veterinary product containing miltefosine, is effective against sporotrichosis caused by S. brasiliensis and S. schenckii in vitro and in infected cells.

Deacetylation by sirtuins is important for Aspergillus fumigatus pathogenesis and virulence

This study shows that sirtuins in Aspergillus fumigatus are important for virulence and pathogenesis, with AfSirE deletion reducing virulence and altering protein acetylation and gene expression.

A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis

The paper identifies conidial surface proteins in Aspergillus fumigatus and shows their role in immune evasion during infection.

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

This study identifies brilacidin as a compound that enhances the antifungal activity of caspofungin against multiple human pathogenic fungi, including overcoming resistance mechanisms.

The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming

This paper shows that Toxoplasma gondii microneme proteins MIC1 and MIC4 bind TLR2 and TLR4 N-glycans to activate innate immune responses and regulate infection outcomes.