Author

N. Metanis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

O. Weil-Ktorza· 6 shared D. Despotovic· 3 shared L. M. Longo· 3 shared B. Dhayalan· 2 shared M. A. Weiss· 2 shared Y. Fridmann-Sirkis· 2 shared Y. Levy· 2 shared A. Gupta· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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6 shared papersBiochemistry

O. Weil-Ktorza

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Se-Glargine I. Chemical Synthesis of a Basal Insulin Analog Stabilized by an Internal Diselenide Bridge

O. Weil-Ktorza, B. Dhayalan, M. A. Weiss, N. Metanis

This paper describes the chemical synthesis of a basal insulin analog with an internal diselenide bridge, demonstrating improved stability and potential therapeutic applications.

ChemBioChem · Feb 2, 2024Peer-reviewedBiochemistry

The Role of Electron Spin, Chirality, and Charge Dynamics in Promoting thePersistence of Nascent Nucleic Acid-Peptide Complexes

P. Vyas, K. Santra, N. Preeyanka, A. Gupta, O. Weil-Ktorza, Q. Zhu, N. Metanis, J. Fransson, L. M. Longo, R. Naaman

This study shows how chirality and spin enhance protein-DNA complex stability through the chiral-induced spin selectivity effect.

bioRxiv · Nov 16, 2023Biophysics

Se-Glargine II. Native Function of a Basal Insulin Analog Stabilized by an Internal Diselenide Bridge

Y.-S. Chen, B. Dhayalan, Y. Yang, O. Weil-Ktorza, N. Metanis, M. A. Weiss

This paper describes an insulin analog with an internal diselenide bridge that maintains native function and stability, potentially improving insulin shelf life and accessibility.

bioRxiv · Jun 24, 2023 · PreprintBiochemistry

Functional Ambidexterity of an Ancient Nucleic Acid-Binding Domain

O. Weil-Ktorza, Y. Fridmann-Sirkis, D. Despotovic, S. Naveh-Tassa, Y. Levy, N. Metanis, L. M. Longo

The paper investigates the functional robustness of the HhH protein family under chiral inversion, finding functional ambidexterity across evolutionary trajectories.

bioRxiv · Mar 6, 2023Biophysics

Peptide-RNA Coacervates as a Cradle for the Evolution of Folded Domains

M. Seal, O. Weil-Ktorza, D. Despotovic, D. S Tawfik, Y. Levy, N. Metanis, L. M Longo, D. Goldfarb

This study investigates how peptide-RNA coacervates influence the structure and dynamics of the HhH motif, suggesting they may have facilitated early protein evolution through oligomerization.

bioRxiv · Apr 10, 2022Biophysics

Primordial emergence of a nucleic acid binding protein via phase separation and statistical ornithine to arginine conversion

L. M. Longo, D. Despotovic, O. Weil-Ktorza, M. J. Walker, J. Jablonska, Y. Fridmann-Sirkis, G. Varani, N. Metanis, D. S. Tawfik

This study demonstrates a transition from phase-separating polypeptides to dsDNA-binding proteins through statistical ornithine-to-arginine conversion and sequence duplication.

bioRxiv · Jan 18, 2020Biochemistry