Author

D. Despotovic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 4 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. S. Tawfik· 4 shared L. M. Longo· 4 shared E. Aharon· 3 shared N. Metanis· 3 shared O. Weil-Ktorza· 3 shared A. Dubovetskyi· 2 shared H. Leader· 2 shared Y. Ashani· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiochemistry

D. S. Tawfik

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Functional Ambidexterity of an Ancient Nucleic Acid-Binding Domain

O. Weil-Ktorza, Y. Fridmann-Sirkis, D. Despotovic, S. Naveh-Tassa, Y. Levy, N. Metanis, L. M. Longo

The paper investigates the functional robustness of the HhH protein family under chiral inversion, finding functional ambidexterity across evolutionary trajectories.

bioRxiv · Mar 6, 2023Biophysics

Peptide-RNA Coacervates as a Cradle for the Evolution of Folded Domains

M. Seal, O. Weil-Ktorza, D. Despotovic, D. S Tawfik, Y. Levy, N. Metanis, L. M Longo, D. Goldfarb

This study investigates how peptide-RNA coacervates influence the structure and dynamics of the HhH motif, suggesting they may have facilitated early protein evolution through oligomerization.

bioRxiv · Apr 10, 2022Biophysics

Widespread Utilization of Diverse Organophosphate Pollutants by Marine Bacteria

D. Despotovic, E. Aharon, O. Trofimyuk, A. Dubovetskyi, K. P. Cherukuri, Y. Ashani, H. Leader, A. Castelli, L. Fumagalli, A. Savidor, Y. Levin, L. M. Longo, E. Segev, D. S. Tawfik

Marine bacteria utilize diverse organophosphate pollutants as a phosphorus source, offering potential for bioremediation.

bioRxiv · Oct 18, 2021 · PreprintMicrobiology

Polyamines Mediate Folding of Primordial Hyper-Acidic Helical Proteins

D. Despotovic, L. M. Longo, E. Aharon, A. Kahana, T. Scherf, I. Gruic-Sovulj, D. S. Tawfik

This study shows polyamines induce folding of a hyper-acidic ancestral protein, suggesting they may have functioned as chemical chaperones in early life.

bioRxiv · Oct 1, 2020Evolutionary Biology

Primordial emergence of a nucleic acid binding protein via phase separation and statistical ornithine to arginine conversion

L. M. Longo, D. Despotovic, O. Weil-Ktorza, M. J. Walker, J. Jablonska, Y. Fridmann-Sirkis, G. Varani, N. Metanis, D. S. Tawfik

This study demonstrates a transition from phase-separating polypeptides to dsDNA-binding proteins through statistical ornithine-to-arginine conversion and sequence duplication.

bioRxiv · Jan 18, 2020Biochemistry

A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents

D. Despotovic, E. Aharon, A. Dubovetskyi, H. Leader, Y. Ashani, D. S. Tawfik

This paper describes a mixture of three phosphotriesterase variants that detoxify all known threat nerve agents.

bioRxiv · Aug 28, 2019Biochemistry