Author

N. Noinaj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. Chen· 3 shared R. Huang· 3 shared C. Dong· 2 shared G. Dong· 2 shared J. Min· 2 shared A. Mesecar· 1 shared B. D. Mackie· 1 shared C. Daczkowski· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

D. Chen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural insight into the dual function of LbpB in mediating Neisserial pathogenesis

N. Noinaj, R. Yadav, S. Govindan, C. Daczkowski, A. Mesecar, S. Chakravarthy

This study presents the structures of LbpB from Neisseria species in complex with lactoferrin, revealing its dual role in iron acquisition and immune evasion.

bioRxiv · Jul 13, 2021Biophysics

Chemoproteomic study uncovers HemK2/KMT9 as a new target for NTMT1 bisubstrate inhibitors

D. Chen, Y. Meng, D. Yu, N. Noinaj, X. Cheng, R. Huang

The paper identifies HemK2/KMT9 as a new target of NTMT1 bisubstrate inhibitor NAH-C3-GPKK through chemoproteomic profiling.

bioRxiv · Apr 13, 2021Biochemistry

Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogs

D. Chen, C. Dong, G. Dong, K. Srinivasan, J. Min, N. Noinaj, R. Huang

This study examines bisubstrate analog interactions with NTMT1 to understand active site plasticity and identifies a 4-C linker analog as the most potent inhibitor.

bioRxiv · Apr 13, 2020Biochemistry

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies

B. D. Mackie, D. Chen, G. Dong, C. Dong, H. Parker, N. Noinaj, C. E. Schaner Tooley, J. Min, R. Huang

This paper designs and characterizes peptidomimetic inhibitors of NTMT1/2, showing high selectivity and cell-permeable activity.

bioRxiv · Apr 13, 2020Biochemistry