Author

N. Papadopoulos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1

Frequent Co-Authors

B. Vogelstein· 4 shared C. Bettegowda· 4 shared K. W. Kinzler· 4 shared L. Dobbyn· 3 shared M. Popoli· 3 shared N. Wyhs· 3 shared S. Zhou· 3 shared A. L. Cook· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

B. Vogelstein

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

A. L. Cook, S. Sur, L. Dobbyn, E. Watson, J. D. Cohen, B. Ptak, B. S. Lee, S. Paul, E. Hsiue, M. Popoli, B. Vogelstein, N. Papadopoulos, C. Bettegowda, K. Gabrielson, S. Zhou, , N. Wyhs

A SMG1 inhibitor disrupts nonsense-mediated decay, increasing expression of neoantigens from truncating mutations and enhancing immune targetable peptides on cancer cells.

bioRxiv · Dec 28, 2023Cancer Biology

ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

J. Rincon-Torroella, M. Dal Molin, B. Mog, G. Han, E. Watson, N. Wyhs, S. Ishiyama, T. Ahmedna, I. Minn, N. S. Azad, C. Bettegowda, N. Papadopoulos, K. W. Kinzler, S. Zhou, B. Vogelstein, , S. Sur

ME3BP-7 is a novel 3BP formulation that resists serum degradation and kills MCT1-high pancreatic cancer cells with low toxicity in mice.

bioRxiv · Jul 23, 2023Cancer Biology

Beyond sequence similarity: cross-phyla protein annotation by structural prediction and alignment

F. Ruperti, N. Papadopoulos, J. Musser, M. Mirdita, M. Steinegger, D. Arendt

This paper introduces MorF, a tool using structural similarity to annotate protein functions in sponges, improving annotation beyond sequence-based methods.

bioRxiv · Jul 5, 2022Evolutionary Biology

An Isogenic Cell Line Panel for Sequence-based Screening of Targeted Anti-cancer Drugs

A. L. Cook, N. Wyhs, S. B. Sur, B. Ptak, M. Popoli, L. Dobbyn, T. Papadopoulos, C. Bettegowda, N. Papadopoulos, B. Vogelstein, S. Zhou, K. W. Kinzler

The paper creates an isogenic cell line panel for drug screening, finding that most lines did not fully inactivate genes but a subset had biallelic disruptions, enabling drug response testing.

bioRxiv · Aug 6, 2021Cancer Biology

Assessing aneuploidy with repetitive element sequencing.

C. Douville, J. D. Cohen, J. Ptak, M. Popoli, J. Schaefer, N. Silliman, L. Dobbyn, R. E. Schoen, J. Tie, P. Gibbs, M. Goggins, C. L. Wolfgang, T.-L. Wang, I.-M. Shih, R. Karchin, , B. Vogelstein

The paper describes a PCR-based assay for detecting aneuploidy in low DNA samples, showing 49% prevalence in non-metastatic cancers and 80% sensitivity when combined with other biomarkers.

bioRxiv · Jun 5, 2019Cancer Biology