Author

T.-L. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:organoid / primary culture· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

I.-M. Shih· 5 shared A. Kiemen· 2 shared D. Wirtz· 2 shared G. C. Russo· 2 shared M. Goggins· 2 shared M.-H. Lee· 2 shared P.-H. Wu· 2 shared Y. S. Rahmanto· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersCancer Biology

I.-M. Shih

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Precision-engineered biomimetics: the human fallopian tube

A. J. Crawford, A. Forjaz, I. Bhorkar, T. Roy, D. Schell, V. Queiroga, K. Ren, D. Kramer, J. Bons, W. Huang, G. C. Russo, M.-H. Lee, B. Schilling, P.-H. Wu, I.-M. Shih, , D. Wirtz

The paper develops a precision-engineered multi-compartment organoid model of the human fallopian tube validated against a 3D single-cell reference map.

bioRxiv · Jun 6, 2023 · PreprintBioengineering

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

M. S. Taylor, W. Connie, P. C. Fridy, S. J. Zhang, Y. Senussi, J. C. Wolters, W.-C. Cheng, J. Heaps, B. D. Miller, K. Mori, L. Cohen, H. Jiang, K. R. Molloy, B. L. Norden, B. T. Chait, , O. H. Yilmaz

This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.

bioRxiv · Jan 25, 2023 · PreprintCancer Biology

Systems medicine dissection of chromosome 1q amplification reveals oncogenic regulatory circuits and informs targeted therapy in cancer

N. Trasanidis, A. Katsarou, K. Ponnusamy, Y.-A. Shen, I. V. Kostopoulos, B. Bergonia, K. Keren, P. Reema, X. Xiao, R. M. Szydlo, P. M. Sabbattini, I. A. Roberts, H. W. Auner, K. N. Naresh, A. Chaidos, , A. Karadimitris

This study identifies oncogenic regulatory circuits driven by chromosome 1q amplification in cancer and proposes targeted therapy strategies using a systems medicine approach.

bioRxiv · Nov 17, 2021Cancer Biology

Development of Small Molecule Inhibitors Targeting PBX1 Transcription Signaling as a Novel Cancer Therapeutic Strategy

T.-L. Wang, I.-M. Shih, Y.-A. Shen, J. Jung, G. D. Shimberg, F.-C. Hsu, Y. S. Rahmanto, S. L. Gaillard, J. Hong, J. Bosch, C.-M. Chuang

This study develops small molecule inhibitors targeting PBX1 transcription signaling, showing they suppress cancer cell growth and re-sensitize resistant tumors.

bioRxiv · Apr 19, 2021Pathology

Multi-compartment tumor organoids

M.-H. Lee, Y. S. Rahmanto, G. C. Russo, P.-h. Wu, D. Gilkes, A. Kiemen, T. Miyamoto, Y. Yu, M. Habibi, I.-M. Shih, T.-L. Wang, D. Wirtz

This paper develops a high-throughput microtechnology to create multi-compartment tumor organoids that mimic tumor microenvironments and improve drug response and tumor progression studies.

bioRxiv · Nov 3, 2020Cancer Biology

Assessing aneuploidy with repetitive element sequencing.

C. Douville, J. D. Cohen, J. Ptak, M. Popoli, J. Schaefer, N. Silliman, L. Dobbyn, R. E. Schoen, J. Tie, P. Gibbs, M. Goggins, C. L. Wolfgang, T.-L. Wang, I.-M. Shih, R. Karchin, , B. Vogelstein

The paper describes a PCR-based assay for detecting aneuploidy in low DNA samples, showing 49% prevalence in non-metastatic cancers and 80% sensitivity when combined with other biomarkers.

bioRxiv · Jun 5, 2019Cancer Biology