N. Phanuphak

Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting

The paper tracks the coreceptor switch of HIV-1 in early infection, finding that a single mutation can drive X4 variants and co-evolution of antigenicity and tropism.

Productive and latent HIV infections originate in resting CD4+ T cells

This study shows that resting CD4+ T cells are the initial source of both productive and latent HIV infections in the earliest stages of detectable infection.

HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections

This study identifies that HIV initially infects diverse CD4+ T cells in blood and lymph nodes, establishing both productive infections and latent reservoirs simultaneously.

Potential biomarker of human papillomavirus 16 L1 methylation for prediction of anal intraepithelial neoplasia in men who have sex with men (MSM)

The paper analyzes HPV16 gene methylation in anal samples from MSM to identify potential biomarkers for anal cancer screening, finding increased L1 gene methylation in higher-grade lesions.

Dendritic cells focus CTL responses toward highly conserved and topologically important HIV epitopes

This study uses dendritic cells to focus CD8+ T cell responses on conserved and topologically important HIV epitopes to prevent immune escape.