S. Horn

Cohesin supercoils DNA during loop extrusion

This study shows cohesin supercoils DNA during loop extrusion, influencing genome architecture through both looping and supercoiling.

TERT expression is associated with metastasis from thin primaries, exhausted CD4+ T cells in melanoma and with DNA repair across cancer entities

This study investigates TERT expression in cancer, finding its association with metastasis, exhausted CD4+ T cells in melanoma, and DNA repair across multiple cancer types.

Interactive webtool for analyzing drug sensitivity and resistance associated with genetic signatures of cancer cell lines

The paper introduces a webtool for analyzing drug sensitivity and resistance in cancer cell lines using genetic data from the GDSC and CCLE databases.

PTK7 is a positive allosteric modulator of GPR133 (ADGRD1) signaling in GBM

This study identifies PTK7 as a positive allosteric modulator of GPR133 signaling in glioblastoma, showing that their interaction enhances receptor activation and is relevant to tumor pathogenesis.

Persister state-directed transitioning and vulnerability in melanoma

This study identifies a compound that induces a persister state in melanoma cells, promoting differentiation and sensitizing them to a prodrug, offering a dual-target strategy for treatment.