Author

N. C. Guilz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

E. Mace· 2 shared M. Borowiak· 2 shared S. Seo· 2 shared Y.-O. Ahn· 2 shared A. Bielinsky· 1 shared A. E. Pezzi· 1 shared A. G. Heaps· 1 shared A. Hung· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

E. Mace

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency

S. Seo, Y.-O. Ahn, S. L. Patil, J. Armetta, M. D. Saturne, E. Hegewisch-Solloa, N. C. Guilz, A. Patel, B. Corneo, M. Borowiak, E. M. Mace

This study shows that allelic bias in GINS4 variants contributes to variable clinical and cellular phenotypes in NK cell deficiency.

bioRxiv · Sep 25, 2023Cell Biology

Replication stress in activated human NK cells induces sensitivity to apoptosis

N. C. Guilz, Y.-O. Ahn, S. Seo, H. Fatima, L. A. Pedroza, R. SONI, N. Wang, D. Egli, E. Mace

This study shows that replication stress in activated human NK cells increases apoptosis and impairs function, linking helicase deficiency to NK cell deficiency.

bioRxiv · Sep 7, 2023Immunology

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

T. R. Ahmad, S. Higuchi, E. Bertaggia, A. Hung, N. Shanmugarajah, N. C. Guilz, J. R. Gamarra, R. A. Haeusler

This study shows that bile acid composition, particularly 12-hydroxylated bile acids, regulates the manganese transporter Slc30a10 in the intestine via lithocholic acid signaling through the vitamin D receptor.

bioRxiv · Feb 11, 2020Cell Biology

Human NK cell deficiency as a result of biallelic mutations in MCM10

E. Mace, S. Paust, M. I. Conte, R. M. Baxley, M. Schmit, N. C. Guilz, M. Mukherjee, A. E. Pezzi, J. Chmielowiec, S. Tatineni, I. K. Chinn, Z. C. Akdemir, S. N. Jhangiani, D. M. Muzny, A. Stray-Pedersen, , J. Orange

This study identifies biallelic MCM10 mutations as a cause of human NK cell deficiency, showing impaired NK cell maturation and function in a patient with CMV susceptibility.

bioRxiv · Nov 7, 2019Immunology

N. C. Guilz · henhao