Molecular Determinants of Tissue Specificity of Flavivirus Nonstructural Protein 1 Interaction with Endothelial Cells
N. T. Lo, S. Roodsari, N. R. Tin, S. B. Biering, E. Harris
This study identifies molecular determinants of flavivirus NS1 that confer tissue-specific endothelial dysfunction and vascular leak, highlighting the role of the wing domain and a three-residue motif.
bioRxiv · Apr 28, 2022Microbiology