Author

S. B. Biering

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

E. Harris· 4 shared B. Castillo-Rojas· 2 shared F. Pahmeier· 2 shared L. H. Yamashiro· 2 shared M. P. Wong· 2 shared N. T. Lo· 2 shared S. F. Blanc· 2 shared X. Nguyenla· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersMicrobiology

E. Harris

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The Inflammasome Pathway is Activated by Dengue Virus Non-structural Protein 1 and is Protective During Dengue Virus Infection

M. P. Wong, E. Y. Juan, S. S. Chelluri, P. Wang, F. Pahmeier, B. Castillo-Rojas, S. F. Blanc, S. B. Biering, R. E. Vance, E. Harris

This study shows DENV NS1 activates inflammasomes in macrophages, leading to IL-1β release without pyroptosis, and that this pathway is protective against DENV infection.

bioRxiv · Sep 21, 2023Immunology

Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses

M. S. Strine, W. L. Cai, J. Wei, M. M. Alfajaro, R. B. Filler, S. B. Biering, S. Sarnik, A. Patil, K. S. Cervantes, C. K. Collings, P. C. DeWeirdt, R. E. Hanna, K. Schofield, C. Hulme, S. Konermann, , C. B. Wilen

This study shows DYRK1A promotes viral entry of SARS-CoV, SARS-CoV-2, and MERS-CoV by regulating ACE2 and DPP4 transcription without its kinase activity.

bioRxiv · Sep 13, 2022 · PreprintMicrobiology

Molecular Determinants of Tissue Specificity of Flavivirus Nonstructural Protein 1 Interaction with Endothelial Cells

N. T. Lo, S. Roodsari, N. R. Tin, S. B. Biering, E. Harris

This study identifies molecular determinants of flavivirus NS1 that confer tissue-specific endothelial dysfunction and vascular leak, highlighting the role of the wing domain and a three-residue motif.

bioRxiv · Apr 28, 2022Microbiology

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

S. B. Biering, F. Tramontini Gomes de Sousa, L. V. Tjang, F. Pahmeier, R. Ruan, S. F. Blanc, T. S. Patel, C. M. Worthington, D. R. Glasner, B. Castillo-Rojas, V. Servellita, N. T. Lo, M. P. Wong, C. M. Warnes, D. R. Sandoval, , E. Harris

This study shows SARS-CoV-2 Spike protein causes barrier dysfunction and vascular leak through integrins and TGF-β signaling, independent of viral replication and ACE2.

bioRxiv · Dec 10, 2021 · PreprintMicrobiology

An intranasal ASO therapeutic targeting SARS-CoV-2

C. Zhu, J. Y. Lee, J. Z. Woo, L. Xu, X. Nguyenla, L. H. Yamashiro, F. Ji, S. B. Biering, E. V. Dis, F. Gonzalez, D. Fox, A. Rustagi, B. A. Pinsky, C. A. Blish, C. Chiu, , A. M. Näär

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

bioRxiv · May 17, 2021Microbiology

Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2

S. B. Biering, E. Van Dis, E. Wehri, L. H. Yamashiro, X. Nguyenla, C. Dugast-Darzacq, T. G. Graham, J. R. Stroumza, G. R. Golovkine, A. W. Roberts, D. M. Fines, J. N. Spradlin, C. C. Ward, T. Bajaj, D. Dovala, , S. A. Stanley

This study screens FDA-approved compounds for antiviral activity against SARS-CoV-2 and identifies 13 effective compounds, including seven new candidates and one synergistic combination with remdesivir.

bioRxiv · Dec 30, 2020Microbiology