BiophysicsNature Structural & Molecular BiologyPeer-reviewed
A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission
T. G. Flower, Y. Takahashi, A. Hudait…·J. H. Hurley
This study determines the structure of human ESCRT-I and shows it forms a helical assembly that scaffolds and mechanically drives membrane scission during HIV-1 budding.
DOI 10.1038/s41594-020-0426-4