Author

T. G. Flower

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein structure prediction· 3 Organism:human· 2 Assay:protein structure· 2 Assay:structural biology· 2 Organism:virus· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. H. Hurley· 4 shared C. Z. Buffalo· 2 shared X. Ren· 2 shared A. Boecker· 1 shared A. Hudait· 1 shared A. K. Stavoe· 1 shared A. L. Yokom· 1 shared A. Pak· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiophysics

J. H. Hurley

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Author profile →

4 papers

Recent·Most cited

Structural Basis for Membrane Recruitment of ATG16L1 by WIPI2 in Autophagy

L. M. Strong, C. Chang, A. Boecker, T. G. Flower, C. Z. Buffalo, X. Ren, A. K. Stavoe, E. L. F. Holzbaur, J. H. Hurley

This study determines the crystal structure of WIPI2 interacting with ATG16L1, revealing the molecular mechanism of ATG16L1 recruitment to the phagophore and its role in autophagy initiation.

bioRxiv · May 14, 2021Cell Biology

Crystallographic molecular replacement using an in silico-generated search model of SARS-CoV-2 ORF8

T. G. Flower, J. H. Hurley

The paper assesses whether an in silico-predicted structure of SARS-CoV-2 ORF8 can serve as a molecular replacement search model, finding it successful in solving the phase problem.

bioRxiv · Jan 5, 2021Biophysics

Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion

T. G. Flower, C. Z. Buffalo, R. M. Hooy, M. Allaire, X. Ren, J. H. Hurley

The paper determines the crystal structure of SARS-CoV-2 ORF8, revealing unique dimerization interfaces that may enable immune evasion.

bioRxiv · Aug 27, 2020Biophysics

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission

T. G. Flower, Y. Takahashi, A. Hudait, K. Rose, N. Tjahjono, A. Pak, A. L. Yokom, X. Liang, H.-G. Wang, F. Bouamr, G. A. Voth, J. H. Hurley

This study determines the structure of human ESCRT-I and shows it forms a helical assembly that scaffolds and mechanically drives membrane scission during HIV-1 budding.

Nature Structural & Molecular Biology · May 18, 2020Peer-reviewedBiophysics