Y. Takahashi

Systematic Discovery of Phage Genes that Inactivate Bacterial Immune Systems

This study identifies phage genes that inactivate bacterial immune systems by testing gene deletions in a phage library against bacterial defense systems.

Diurnal regulation of SOS Pathway and Sodium Excretion Underlying Salinity Tolerance of Vigna marina

This study identifies diurnal regulation of the SOS pathway and sodium excretion mechanisms in Vigna marina, revealing a QTL region with structural rearrangements and cis-regulatory motifs linked to salt tolerance.

The minimal SUF system can substitute for the canonical iron-sulfur cluster biosynthesis systems by using inorganic sulfide as the sulfur source.

Neurogenomic diversity enhances collective antipredator performance in Drosophila

The paper identifies genetic loci contributing to collective antipredator behavior in Drosophila through a genome-wide higher-level association study.

Effect of phage variation on Shiga toxin 2 (Stx2) production and the virulence of Stx-producing Escherichia coli

This study examines how variations in Stx2 phages affect Stx2 production and virulence in O145:H28 STEC strains, revealing differences in production levels based on phage type and repressor type.

Comparative analyses of adsorbed circulating proteins in the PMMA and PES hemodiafilters in patients on predilution online hemodiafiltration

This study compares protein adsorption by PMMA and PES hemodiafilters in OL-HDF, finding PMMA adsorbs more inflammatory proteins like IL-6 and beta-2 microglobulin.

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface

This paper identifies a class of human antibodies that bind a conserved HA head-stem interface epitope, offering broad protection against influenza A serotypes in mice.

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

This study develops bispecific antibodies that restore effectiveness against SARS-CoV-2 variants resistant to existing antibodies by combining non-neutralizing antibodies targeting different epitopes.

CO2 Response Screen in Grass Brachypodium Reveals Key Role of a MAP-Kinase in CO2-Triggered Stomatal Closure

This study identifies a MAP-kinase, BdMPK5, as critical for CO2-induced stomatal closure in Brachypodium, using forward genetics and structural modeling.

Evolution of wheat blast resistance gene Rmg8 accompanied by differentiation of variants recognizing the powdery mildew fungus

The paper traces the evolutionary origin of wheat blast resistance gene Rmg8 and shows its ability to recognize both wheat blast and powdery mildew pathogens.

Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics

This study identifies Atf3 as a key regulator of transition from compensation to dysfunction in female mitochondrial cardiomyopathy using single-cell transcriptomics.

Mechanical signaling through membrane tension induces somal translocation during neuronal migration

This study shows that mechanical signaling via membrane tension and mechanosensitive ion channels links leading process extension to somal translocation during neuronal migration.

Plasticity of circadian and circatidal rhythms in activity and transcriptomic dynamics in a freshwater snail

The paper examines circadian and circatidal rhythms in a freshwater snail, finding that both tidal and nontidal populations exhibit circatidal rhythms after exposure to a simulated tidal cycle, with tidal populations showing more circatidal oscillating genes.

Brd4-Nutm1 fusion gene initiates NUT carcinoma in vivo

This study creates a genetically engineered mouse model of NUT carcinoma by inducing the Brd4::Nutm1 fusion gene, showing it can initiate aggressive tumors with features similar to human NC.

Developmental noise and phenotypic plasticity are correlated in Drosophila simulans

This study quantifies phenotypic plasticity and developmental noise in Drosophila simulans and finds a positive correlation between them, suggesting they contribute to evolvability.

Genetic variations in foraging habits and their developmental noise in Drosophila

The paper examines genetic variation and developmental noise in foraging traits of Drosophila lutescens, finding shared genetic basis for variation in locomotive activity and resource preferences.

Characterization of Tryptophan Oxidation Affecting D1 Degradation by FtsH in the Photosystem II Quality Control of Chloroplasts

This study shows that Trp oxidation at the N-terminus of D1 protein enhances FtsH-mediated degradation during high-light stress in PSII repair.

Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

The paper combines gene supplementation and genome editing to treat spinal muscular atrophy in mice, showing long-term therapeutic benefits.

The genomics and evolution of inter-sexual mimicry and female-limited polymorphisms in damselflies

This study identifies the genomic basis of female-limited morphs and male mimicry in damselflies, revealing structural variants and transposable element activity driving these phenotypes.

Viruses encode tRNA and anti-retron to evade bacterial immunity

This study identifies two viral strategies to evade bacterial retrons: supplying tRNATyr to counteract retron 78 and using Rad to degrade retron noncoding RNA precursors.

MPK12 in stomatal CO2 signaling: function beyond its kinase activity

This study investigates the non-catalytic role of MPK12 in CO2-induced stomatal responses, showing that its interaction with HT1 is CO2/HCO3--dependent and kinase activity-independent.

Identification of inosine monophosphate dehydrogenase as a potential target for anti-monkeypox virus agents

This study identifies IMPDH as a potential target for anti-monkeypox virus agents by showing that compounds targeting this enzyme inhibit MPXV replication more effectively than existing treatments.

Disorganization of basement membrane zone architecture causes impaired melanocyte inhabitation in vitiligo

This study identifies disorganized basement membrane zone architecture and MMP2 overexpression in dermal fibroblasts as contributors to melanocyte loss in vitiligo.

Curvature Sensing and Membrane Remodeling of the VPS37A N-terminal Domain during Autophagy

This study identifies two hydrophobic motifs in VPS37A that bind curved membranes, essential for autophagosome biogenesis.

Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumor

A low carbohydrate diet suppresses neuroendocrine tumor onset and progression by reducing insulin signaling and PI3K-Akt-mTOR pathway activity in mouse models and correlates with better prognosis in patients.

Cleavage of α-1,4-Glycosidic Linkages by the Glycosylphosphatidylinositol-Anchored α-Amylase AgtA Decreases the Molecular Weight of Cell Wall α-1,3-Glucan in Aspergillus oryzae

This study shows that AoAgtA, a GPI-anchored α-amylase in Aspergillus oryzae, cleaves -1,4-glycosidic bonds in the spacer region of cell wall -1,3-glucan, reducing its molecular weight.

Mycelial differentiation linked avermectin production in studied with Raman imaging

This study uses Raman imaging to show how avermectin production correlates with mycelial differentiation stages in Streptomyces avermitilis under different culture conditions.

Detecting frequency-dependent selection through the effects of genotype similarity on fitness components

The paper introduces a method to detect frequency-dependent selection by analyzing genotype similarity's effect on fitness components using regression analysis in Arabidopsis and damselfly data.

Potential anti-monkeypox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatments

This study identifies atovaquone, mefloquine, and molnupiravir as potential anti-monkeypox virus drugs, with atovaquone showing enhanced efficacy when combined with tecovirimat.

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.

The paper develops Fc-modified SARS-CoV-2 neutralizing antibodies effective against variants, showing reduced viral titers and lung damage in animal models.