A. L. Yokom

Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation

The paper determines the structure of ATG9A's C-terminal tail interacting with the ULK1 complex's ATG13:ATG101 HORMA dimer, revealing how this interaction facilitates mitophagy.

Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation

The paper determines the cryo-EM structure of the active FLCN complex, revealing how it selectively regulates mTORC1 substrates TFEB and TFE3.

Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1

This study shows that CHMP1B and IST1 can sever membranes through a friction-driven mechanism, requiring constriction and extensional force, but not VPS4 or spastin.

Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy

This study investigates how different cargo receptors stimulate LC3 lipidation in selective autophagy using GUVs and shows varying requirements for autophagy core complexes.

The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment

This study shows NDP52 allosterically activates ULK1 complex membrane recruitment via FIP200 coiled-coil conformational changes, essential for xenophagy and mitophagy.

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission

This study determines the structure of human ESCRT-I and shows it forms a helical assembly that scaffolds and mechanically drives membrane scission during HIV-1 budding.

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer

The paper identifies the C-shaped dimeric structure of FIP200's N-terminal domain and its role in organizing the ULK complex by directly binding ATG13.

Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy