Structural insights into the complex of oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
M. Tariq, T. Ikeya, N. Togashi, L. Fairall, S. Kamei, S. Mayooramurugan, L. R. Abbott, A. Hasan, C. Bueno-Alejo, S. Sukegawa, B. Romartinez-Alonso, M. A. Muro Campillo, A. J. Hudson, Y. Ito, J. W. Schwabe, , K. Tanaka
This study investigates the structural interaction between oncogenic KRas4BG12V and Rgl2RA, revealing a unique tetrameric complex formation that explains its hyperactivation of the RalA/B pathway.
bioRxiv · Oct 10, 2022Biochemistry