Author

L. R. Abbott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

K. Tanaka· 2 shared A. Hasan· 1 shared A. J. Hudson· 1 shared A. M. Fry· 1 shared B. Romartinez-Alonso· 1 shared C. Bueno-Alejo· 1 shared C. Dominguez· 1 shared J. W. Schwabe· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

K. Tanaka

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Endogenous oncogenic KRAS expression increases cell proliferation and motility in near-diploid hTERT RPE-1 cells

N. L. Hindul, L. R. Abbott, S. M. D. Adan, K. R. Straatman, A. M. Fry, K. Hirota, K. Tanaka

This study shows that endogenous oncogenic KRAS mutations increase cell proliferation and motility in hTERT RPE-1 cells, with differential responses to targeted therapies.

bioRxiv · Sep 8, 2023Cell Biology

Structural insights into the complex of oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator

M. Tariq, T. Ikeya, N. Togashi, L. Fairall, S. Kamei, S. Mayooramurugan, L. R. Abbott, A. Hasan, C. Bueno-Alejo, S. Sukegawa, B. Romartinez-Alonso, M. A. Muro Campillo, A. J. Hudson, Y. Ito, J. W. Schwabe, , K. Tanaka

This study investigates the structural interaction between oncogenic KRas4BG12V and Rgl2RA, revealing a unique tetrameric complex formation that explains its hyperactivation of the RalA/B pathway.

bioRxiv · Oct 10, 2022Biochemistry