Author

N. Villa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

C. S. Fraser· 2 shared B.-S. Shin· 1 shared C. Alvarado· 1 shared C. P. Lapointe· 1 shared E. Montabana· 1 shared I. S. Fernandez· 1 shared J. D. Puglisi· 1 shared J. Wang· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

C. S. Fraser

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2 papers

Recent·Most cited

Human eukaryotic initiation factor 4G directly binds the 40S ribosomal subunit to promote efficient translation.

N. Villa, C. S. Fraser

This study identifies a direct interaction between eIF4G and the 40S ribosomal subunit, independent of eIF3, and shows that the eIF4G-RBD enhances translation without requiring m7G cap or mRNA tethering.

bioRxiv · Sep 29, 2023Biochemistry

eIF5B and eIF1A remodel human translation initiation complexes to mediate ribosomal subunit joining

C. P. Lapointe, R. Grosely, M. Sokabe, C. Alvarado, J. Wang, E. Montabana, N. Villa, B.-S. Shin, T. E. Dever, C. S. Fraser, I. S. Fernandez, J. D. Puglisi

This study uses single-molecule techniques and cryo-EM to show how eIF1A and eIF5B remodel initiation complexes to facilitate ribosomal subunit joining during translation initiation.

bioRxiv · Dec 9, 2021Biophysics